Lower plasma levels of high-density lipoproteins in adolescents with type 2 diabetes have been associated with a higher pulse wave velocity, a marker of arterial stiffness. Evidence suggests that HDL proteins or particle subspecies are altered in T2D and these may drive these relationships. In this work, we set out to reveal any specific proteins and subspecies that are related to arterial stiffness in youth with T2D from proteomics data. Plasma and PWV measurements were previously acquired from lean and T2D (...) adolescents. Each plasma sample was separated into 18 fractions and evaluated by mass spectrometry. Then, we applied a validated network-based computational approach to reveal HDL subspecies associated with PWV. Among 68 detected phospholipid-associated proteins, we found that seven were negatively correlated with PWV, indicating that they may be atheroprotective. Conversely, nine proteins show positive correlation with PWV, suggesting that they may be related to arterial stiffness. Intriguingly, our results demonstrate that apoA-I and histidine-rich glycoprotein may reverse their protective roles and become antagonistic in the setting of T2D. Furthermore, we revealed two arterial stiffness-associated HDL subspecies, each of which contains multiple PWV-related proteins. Correlation and disease association analyses suggest that these HDL subspecies might link T2D to its cardiovascular-related complications. (shrink)

This essay focuses on an issue arising from within an anti-essentialist perspective on sexual identity: how is it possible to explain the political impetus inhering in a category such as 'woman' without having recourse to a set of positive properties that would somehow fix her identity in advance? I examine how a particular theoretical outlook, social postmodernism, attempts to address this issue, and argue that, ultimately, social postmodernism generates its own impasse which I call social foundationalism - an impasse which (...) is structurally similar to biological foundationalism. I invoke discourse -theoretic concepts to introduce the psychoanalytic categories of master signifier and symbolic identification. This is done in order to suggest how Lacanian psychoanalysis permits us to theorize sexual difference in a way that avoids both biological foundationalism and social foundationalism. Key Words: discourse theory • identification • identity • Lacan • poststructuralism • psychoanalysis • sexual difference • social postmodernism. (shrink)

Amodel for inventing newsignals is introduced in the context of sender–receiver games with reinforcement learning. If the invention parameter is set to zero, it reduces to basic Roth–Erev learning applied to acts rather than strategies, as in Argiento et al. (Stoch. Process. Appl. 119:373–390, 2009). If every act is uniformly reinforced in every state it reduces to the Chinese Restaurant Process—also known as the Hoppe–Pólya urn—applied to each act. The dynamics can move players from one signaling game to another during (...) the learning process. Invention helps agents avoid pooling and partial pooling equilibria. (shrink)

We first argue that there are cases of “blameless non-belief.” That is, some people—through no fault of their own—fail to enter into a conscious relationship with God. But if so, then it would be unjust of God to make certain particular goods depend upon one having a conscious relationship with God. So, given that God is just, then despite what some theists believe, a relationship with God cannot be a necessary condition for the attainment of these goods; there might, e.g., (...) be atheists in heaven, even assuming that theism is true. This implies that religion is a far less important component of people’s lives than many might think. (shrink)

Biography of Habermas -- Critical theory -- Habermas and his works -- An assessment of the impact of Habermas -- Conclusion.

To assess ethics pedagogy in science and engineering, we developed a new tool called the Engineering and Science Issues Test. ESIT measures moral judgment in a manner similar to the Defining Issues Test, second edition, but is built around technical dilemmas in science and engineering. We used a quasi-experimental approach with pre- and post-tests, and we compared the results to those of a control group with no overt ethics instruction. Our findings are that several stand-alone classes showed a significant improvement (...) compared to the control group when the metric includes multiple stages of moral development. We also found that the written test had a higher response rate and sensitivity to pedagogy than the electronic version. We do not find significant differences on pre- test scores with respect to age, education level, gender or political leanings, but we do on whether subjects were native English speakers. We did not find significant differences on pre- test scores based on whether subjects had previous ethics instruction; this could suggest a lack of a long-term effect from the instruction. (shrink)

Some physicians refuse to perform life-sustaining interventions, such as tracheostomy, on patients who are very likely to remain permanently unconscious. To explain their refusal, these clinicians often invoke the language of “futility”, but this can be inaccurate and can mask problematic forms of clinical power. This paper explores whether such refusals should instead be framed as conscientious objections. We contend that the refusal to provide interventions for patients very likely to remain permanently unconscious meets widely recognized ethical standards for the (...) exercise of conscience. We conclude that conscientious objection to tracheostomy and other life-sustaining interventions on such patients can be ethical because it does not necessarily constitute a form of invidious discrimination. Furthermore, when a physician frames their refusal as conscientious objection, it makes transparent the value-laden nature of their objection and can better facilitate patient access to the requested treatment. (shrink)

We formulate a new modal ontological argument; specifically, we show that there is a possible world in which an entity that has at least the property of omnipotence exists. Then we argue that if such an entity is possible, it is necessary as well.

Our purpose in this article is to identify and suggest resolution for two core problematics of grounded theory. First, while grounded theory provides transparency to one part of the conceptualization process, where codes emerge directly from the data, it provides no such systematic or transparent way for gaining insight into the conceptual relationships between discovered codes. Producing a grounded theory depends not only on the definition of conceptual pieces, but the delineation of a relationship between at least two of those (...) pieces. Second, the conceptualization process of grounded theory is done in hierarchical fashion, where individual codes emerge from the data but then are used to generate insight into more general concepts and thematic statements. But various works on grounded theory have failed to provide any systematic way of using data specific levels of scale (the codes) to gain insight into more macro levels of scale (concepts and themes). We offer fractal concept analysis as a means of resolving both of these issues. By using a logic structure generator, fractal concept analysis delineates self-similar conceptual frameworks at various levels of abstraction, yielding a method for linking concepts together within and between levels of scale encountered in the grounded theory coding and categorization process. We conclude that this fractal analytic technique can bolster the aims of grounded theory as a formalized and systematic process for generating theory from empirical data. (shrink)

This article summarizes a National Institute of Mental Health workshop that was convened to address the ethical and methodological issues that arise when conducting controlled psychosocial interventions research and introduces 6 thoughtful and inspiring papers prepared by workshop participants. These papers, on topics ranging from informed consent to ethnic minority issues, reflect the depth and breadth of expertise represented by the multidisciplinary group of scientists and ethicists present at the meeting. More extensive follow-up, particularly from federal research applications and publications, (...) of how investigators balance the need for strong research design with ethical considerations may help advance the science of psychosocial intervention research. (shrink)

For observers of pharmaceutical regulation and the Food and Drug Administration, these are uncertain times. Events in late 2016 raised concerns that the FDA's evidentiary standards were being weakened, compromising the agency's ability to adequately perform its regulatory and public health responsibilities. Two developments most directly contributed to these fears—the approval of eteplirsen, a treatment for Duchenne muscular dystrophy, against the recommendations of both FDA staff and an advisory committee and the December 2016 signing of the 21st Century Cures Act, (...) which encouraged greater use by the FDA of “real-world” evidence not obtained through randomized controlled trials. The arrival of the Trump administration—with its deregulatory, industry-friendly approach—has only amplified concerns over the future of the FDA. It is too early to know whether the recent developments are truly harbingers of an FDA less likely to prevent unsafe or ineffective products from reaching the market. But elements in the two events—the role of patient narratives in deliberations regarding eteplirsen and the enthusiasm for real-world evidence in the 21st Century Cures Act—raise critical issues for the future of evidence in the FDA's work. The rigorous, inclusive approach under way to consider issues related to real-world evidence provides a model for a similarly needed inquiry regarding public participation in FDA decision-making. (shrink)

A key source of support for the view that challenging people’s beliefs about free will may undermine moral behavior is two classic studies by Vohs and Schooler (2008). These authors reported that exposure to certain prompts suggesting that free will is an illusion increased cheating behavior. In the present paper, we report several attempts to replicate this influential and widely cited work. Over a series of five studies (sample sizes of N = 162, N = 283, N = 268, N (...) = 804, N = 982) (four preregistered) we tested the relationship between (1) anti-free-will prompts and free will beliefs and (2) free will beliefs and immoral behavior. Our primary task was to closely replicate the findings from Vohs and Schooler (2008) using the same or highly similar manipulations and measurements as the ones used in their original studies. Our efforts were largely unsuccessful. We suggest that manipulating free will beliefs in a robust way is more difficult than has been implied by prior work, and that the proposed link with immoral behavior may not be as consistent as previous work suggests. (shrink)

The process of engaging in historical empathy holds the potential for significant curricular and dispositional benefits for students in history classrooms. In order to realize these benefits, classroom teachers must be able to integrate historical empathy into their existing planning and teaching; a process that would benefit from empirical examination. This single subject case study examined the pedagogical reasoning process of an experienced classroom teacher who integrated historical empathy into an existing instructional unit designed to foster student knowledge of social (...) control as an enduring historical understanding. The findings of this study suggest that experienced teachers may only be able to partially anticipate the unique pedagogical needs integrating historical empathy requires, and that a holistic examination of pedagogical reasoning during all phases of planning and teaching may be most suitable for the task. (shrink)

We first argue that there are cases of “blameless non-belief.” That is, some people—through no fault of their own—fail to enter into a conscious relationship with God. But if so, then it would be unjust of God to make certain particular goods depend upon one having a conscious relationship with God. So, given that God is just, then despite what some theists believe, a relationship with God cannot be a necessary condition for the attainment of these goods; there might, e.g., (...) be atheists in heaven, even assuming that theism is true. This implies that religion is a far less important component of people’s lives than many might think. (shrink)

We argue that the set of humanly known mathematical truths (at any given moment in human history) is finite and so recursive. But if so, then given various fundamental results in mathematical logic and the theory of computation (such as Craig’s in J Symb Log 18(1): 30–32(1953) theorem), the set of humanly known mathematical truths is axiomatizable. Furthermore, given Godel’s (Monash Math Phys 38: 173–198, 1931) First Incompleteness Theorem, then (at any given moment in human history) humanly known mathematics must (...) be either inconsistent or incomplete. Moreover, since humanly known mathematics is axiomatizable, it can be the output of a Turing machine. We then argue that any given mathematical claim that we could possibly know could be the output of a Turing machine, at least in principle. So the Lucas-Penrose (Lucas in Philosophy 36:112–127, 1961; Penrose, in The Emperor’s new mind. Oxford University Press, Oxford (1994)) argument cannot be sound. (shrink)

What are the non-monetary dimensions of selling sex? This article offers a cultural approach to the question of sexual labors, drawing on field observations and interviews in a community of gay men in Dakar, Senegal. Removing the notion of sexual labors from the stigmatized zone of “survival sex,” I explore the affective, extramonetary dimensions of sexual labors. The men in this study labor not simply to make money. Instead, I argue that against a highly gendered cultural backdrop, one where male (...) admiration is often written synonymously with money and gift giving, gay men experience a validation of their self-worth and homoerotic attraction through sexual labors. The extent to which they derive recognition from sexual labors not only subverts the gendered heteronormative paradigm, but also is paradoxically conditioned by it. Beyond sexual labors, however, this article also engages a broader question—how do gay men forge a positive sense of self amidst a variety of oppressive forces? The answer is not only through sexual labors, but also through initiation into a gay identity and community, an ethos of generosity and solidarity, kinship ties, and an ethic of sexual discovery, each taking shape alongside these labors. (shrink)

This paper has two aims: (1) to point the way towards a novel alternative to cognitive theories of emotion, and (2) to delineate a number of different functions that the emotions play in cognition, functions that become visible from outside the framework of cognitive theories. First, I hold that the Higher Order Representational (HOR) theories of consciousness — as generally formulated — are inadequate insofar as they fail to account for selective attention. After posing this dilemma, I resolve it in (...) such a manner that the following thesis arises: the emotions play a key role in shaping selective attention. This thesis is in accord with A. Damasio’s (1994) noteworthy neuroscientific work on emotion. I then begin to formulate an alternative to cognitive theories of emotion, and I show how this new account has implications for the following issues: face recognition, two brain disorders (Capgras’ and Fregoli syndrome), the frame problem in A. I., and the research program of affective computing. (shrink)

Comparative assessments of national bioethics commissions in the United States commonly look at the differences among these groups over their forty‐year history. A particular focus has been differences in the membership, mission, methods, and reports of the President's Council on Bioethics, which was active from 2001 until 2009, compared to those of its predecessors and the recent Presidential Commission for the Study of Bioethical Issues, active from 2009 until 2016. The differences are real, but disproportionate attention to them can obscure (...) the substantial similarities in commissions’ structure and function throughout the history of expert bioethics advice to government. As the Trump administration considers what role, if any, a bioethics commission will play in its work, it would be well served to consider how choices regarding the design of such a group and the topics it examines can best facilitate the unique contributions it can make to the government and to the country. (shrink)

Objective: Compassion has been associated with eudaimonia and prosocial behavior, and has been regarded as a virtue, both historically and cross-culturally. However, the psychological study of compassion has been limited to laboratory settings and/or standard survey assessments. Here, we use an experience sampling method (ESM) to compare naturalistic assessments of compassion with standard assessments, and to examine compassion, its variability, and associations with eudaimonia and prosocial behavior. -/- Methods: Participants took a survey which included standard assessments of compassion and eudaimonia. (...) Then, over four days, they were repeatedly asked about their level of compassion, eudaimonia, and situational factors within the moments of daily life. Finally, prosocial behavior was tested using the Dual Gamble Task and an opportunity to donate task winnings. -/- Results: Analyses revealed within-person associations between ESM compassion and eudaimonia. ESM compassion also predicted eudaimonia at the next ESM time point. While not impervious to situational factors, considerable consistency was observed in ESM compassion in comparison with eudaimonia. Further, ESM compassion along with eudaimonia predicted donating behavior. Standard assessments did not. -/- Conclusion: Consistent with virtue theory, some individual’s reports displayed a probabilistic tendency toward compassion, and ESM compassion predicted ESM eudaimonia and prosocial behavior toward those in need. (shrink)

This paper presents methods to visualize the structure of trees that occur in genetic programming. These methods allow for the inspection of structure of entire trees even though several thousands of nodes may be involved. The methods also scale to allow for the inspection of structure for entire populations and for complete trials even though millions of nodes may be involved. Examples are given that demonstrate how this new way of “seeing” can afford a potentially rich way of understanding dynamics (...) that underpin genetic programming. The examples indicate further studies that might be enabled by visualizing structure at these scales. (shrink)

This article approaches the topics of invention and innovation by way of cultural theory. Building on the works of Ferdinand de Saussure and John Austin, the article offers definitions of invention and innovation in semiotic and performative terms. It conceptualizes invention as a process of resignification, and frames innovation as a felicitous performative. Structuralist theory appears to foreclose the potential for these two terms to exist in the empirical world. This article explores these barriers but also locates conceptual spaces for (...) invention and innovation, and identifies these phenomena as they occur in contemporary empirical sites. (shrink)

The position I defend in this paper is that both prisoners and ex-prisoners, at least within present U.S. society, experience a form of oppression that can be distinguished from that inflicted upon other structurally disadvantaged groups. As a result of these U.S. conditions, I also argue that those who have not been or are not currently incarcerated may possess some unearned advantages, similar to but also different from other forms of privilege, such as those based upon race, class, gender, sexuality, (...) and ability. In the first section, I investigate three definitions of oppression to articulate my thesis of prisoner oppression, using the work of Marilyn Frye, Kenneth Clatterbaugh, and Ann E. Cudd. In the second section, I respond to three objections against my thesis. I conclude in the third section with some thoughts on how the preceding arguments should affect the dominant discourse regarding prison reform and abolition. (shrink)

Introduction -- Is the truth stranger than fiction? -- The emergence and analysis of the postmodern -- Baudrillard and his works on social theory -- An assessment of postmodernism and Baudrillard -- Conclusion.

Introduction -- Social theory and enlightenment project -- Contemporary social theory -- Foucault -- Postmodernism -- References.

Introduction : why Foucault? -- Foucault and impact on applied social science -- The Foucauldian relevance of governmentality and power to helping professions -- Foucault's legacy: Judith Butler, performance and social work -- Conclusion.

Introduction -- The development of feminist social theory -- Gender and class -- The aging body and gender -- Conclusion.

What is social philosophy and age? -- The development of social philosophies of age and aging -- Foucault, age and social philosophy -- Time to recognise personhood and social philosophy : the case of age identity? -- References -- Index.

Introduction -- Methods for thinking -- The making of the modern subject -- Implications -- Example 1 of a Foucauldian approach : aging and prisons -- Example 2 of a Foucualdian approach : social work -- Summary.

Jon Stewart's continued criticism of the inconsistency and irrationality of the American media, the notion of truthiness has relevance for any fan of The Daily Show. This chapter looks a little bit more closely at two notions of truthiness. Focusing on the first sense, it draws some parallels between truthiness and paradigm cases of motivated epistemic irrationality like wishful thinking and self‐deception. Then, it turns to the second sense to see if relying on our guts in the way Colbert suggests (...) might sometimes be rational. (shrink)

Scott Aikin recently claimed that pragmatism and phenomenology are incompatible. Pragmatic naturalism is incompatible with phenomenology’s anti-naturalism. Therefore, pragmatists trying to appropriate insights from phenomenology encounter a dilemma: either reject naturalism and thereby pragmatism, or reject anti-naturalism and thereby phenomenology. I will argue that Aikin’s dilemma is unmerited, especially in the case of John Dewey, because he has misidentified its horns. Given his definition of pragmatic naturalism, the classical pragmatists are neither naturalists nor pragmatists. His discussion of “phenomenology” misconstrues phenomenological (...) method as subjective self-reporting, which hamstrings his assessment of phenomenology and its prospects of reconciliation with pragmatism. I hope to engage and dispel not only Aikin’s dilemma, but also common preconceptions about the intersection of pragmatism and phenomenology. They may be reconciled, although there are antipathies, of which I will discuss Dewey’s principle of continuity. (shrink)